Dr. Mario 64 is a puzzle game based on the original Dr. Mario. It was developed by Newcome and published by Nintendo, released for the Nintendo 64 in 2001, and is an enhanced remake of the original Dr. Mario, which was released for the NES and Game Boy in 1990.
The flu season has come about, and it's Dr. Mario's duty to use his Megavitamins to heal the people of the land. However, Wario, wanting to have the fame that Mario has, attempts to steal the Megavitamins, but to no avail. Afterwards, Mad Scienstein and Rudy the clown (from Wario Land 3) steal the Megavitamins, and both Dr. Mario and Wario go after him. Throughout their adventure, both of them meet up with many creatures from Wario Land 3. Most of the time the fights that emerge are really misunderstandings. For example, you may accidentally bump into a creature, who gets angry and retaliates. Dr. Mario and Wario follow Mad Scienstein to Rudy's castle, where you must fight Rudy to take back the vitamins. If you complete the game on normal or hard mode without continuing, you will play one more stage after defeating Rudy. The opponent is Metal Mario if you used Wario and Vampire Wario if you used Dr. Mario. If you complete the game on hard mode without continuing a hint will appear. From this point on if you highlight hard mode and press the 'Z' button hard will change to S-Hard.
Dr. Mario 64 plays the same as its predecessors for the most part. Dr. Mario throws Megavitamins into a jar full of Viruses, and lining up a combination of Viruses and Megavitamins (four at minimum), they disappear. There are three types of Viruses - the Red Virus (Fever), the Blue Virus (Chill) and the Yellow Virus (Weird), with a Megavitamin color designed to kill them. It includes the main songs from the original Dr. Mario, Fever and Chill, but it also includes two new songs called Cube and Que Que.
Dr. Mario 64 features many different modes of play. The first one is "Classic mode", which features a similar set-up and design to earlier Dr. Mario video games. The second mode of play is called "Story mode". In it, the player may take control of either Dr. Mario or Wario to track down the stolen Megavitamins, battling computer players on the way. Dr. Mario 64 also features a mode where the player may battle against the computer as any character the player has played as or fought against. Up to four players may play Dr. Mario 64 at once in the Multiplayer mode, which is designed similarly to the CPU VS. mode.
Dr. Mario 64 features a mode called "Flash mode", where the player must focus on clearing flashing viruses. Also included is a "Marathon mode", which consists of a never-ending rising field of viruses. This mode does not end until the player quits or loses. Another mode is the "Score Attack mode", where the player is given three minutes to clear all of the viruses as well as get a high score.